Production of neuraminidase by Micromonospora viridifaciens

Abstract

A range of microorganisms were screened for new and high producer strains of neuraminidase (EC 3.2.1.18). High neuraminidase activity was found in the culture filtrates of Actinomycetes of the genus Micromonospora, and Micromonospora viridifaciens showed the highest enzyme activity. Neuraminidase production by M. viridifaciens was highly induced by the presence of the substrate colominic acid and the product N-acetylneuraminic acid. The purified neuraminidase of M. viridifaciens could cleave α(2-3), α(2-6), and α(2-8) glycosidic linkages. © 1987.