Studies on the Laccase-Catalyzed Oxidation of 4-Hydroxy-Chalcones

Abstract

The laccase-catalyzed oxidation of a series of substituted 4-hydroxy-chalcones has been investigated. The main isolated dimeric products were, as expected, racemic mixtures of trans-2,3-dihydrobenzofuran derivatives, always co-eluted with an additional isomeric dimer with an open structure. The two enantiomers, as well as the co-eluted dimeric isomer could be isolated by semi-preparative HPLC with a chiral column and were fully characterized. (Figure presented.).