Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series

Nolan R. Mente; Andrew J. Wiemer; Jeffrey D. Neighbors; John A. Beutler; Raymond J. Hohl; David F. Wiemer

Journal Article

Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series

Bioorganic and Medicinal Chemistry Letters (2007) 17(4) 911-915

DOI: 10.1016/j.bmcl.2006.11.096

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Abstract

Total synthesis of the (R,R,R)- and (S,S,S)-enantiomers of the natural product schweinfurthin F has been completed. Comparisons of spectral data and optical rotations with those reported for the natural product, as well as a variety of bioassay data, allow assignment of the natural material as the (R,R,R)-isomer. © 2006 Elsevier Ltd. All rights reserved.

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Mente, N. R., Wiemer, A. J., Neighbors, J. D., Beutler, J. A., Hohl, R. J., & Wiemer, D. F. (2007). Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series. Bioorganic and Medicinal Chemistry Letters, 17(4), 911–915. https://doi.org/10.1016/j.bmcl.2006.11.096

Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series

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