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Herpes simplex virus UL14 protein blocks apoptosis

Microbiology and Immunology
DOI: 10.1111/j.1348-0421.2003.tb03432.x
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Abstract

We report that an HSV-2 UL14 protein expressing cell line (14/HEp-2) was more resistant to apoptosis induced by osmotic shock and certain drugs than its parental cell line. Furthermore, HSV-1 UL14 protein deletion virus (UL14D) showed weaker inhibition of apoptosis compared to the rescued virus UL14R. The protein's anti-apoptotic function may derive from its heat shock protein-like properties.

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Yamauchi, Y., Daikoku, T., Goshima, F., & Nishiyama, Y. (2003). Herpes simplex virus UL14 protein blocks apoptosis. Microbiology and Immunology. Center for Academic Publications Japan. https://doi.org/10.1111/j.1348-0421.2003.tb03432.x

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