Protective effect of Ficus infectoria plant extract against fructose induced hyperlipidemia and hyperglycemia in rats

Abstract

The main aim of this study is to explore the antihyperlipidemic and hypoglycemic potential of the methanolic extract of Ficus infectoria in Wistar rats. Hyperlipidemia and hypoglycemia in rats were induced by fructose solution (10% w/v, p.o., ad libitum) for 3rd and 8th weeks respectively. These activities were measured by estimating the triglyceride, total cholesterol, LDL, VLDL, HDL and serum glucose levels. F. infectoria at 200mg/kg and 400mg/kg showed significant effect. Fructose feeding increased serum biochemical parameters like triglyceride, total cholesterol, LDL, VLDL and serum glucose levels while decreases the HDL level. In fructose fed rats, F. infectoria at 200 mg/kg and 400 mg/kg significantly prevented the increase in serum biochemical parameters while decrease in HDL level. The present study indicates that methanolic extract of F. infectoria has Antihyperlipidemic and hypoglycemic. In future it may be useful in the management of insulin resistant.