Analgesic and anti-inflammatory properties of aqueous extract of deverra scoparia coss and dur obtained from Tamanrasset, Algeria

4Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.

Abstract

Purpose: To determine the toxicity, anti-inflammatory and analgesic properties of Deverra scoparia Coss. & Dur. and the phenolic compounds involved Methods: The aqueous extract of Deverra scoparia Coss. & Dur. was intra-gastrically administered at increasing doses (2, 4, 8, 12 and 16 g/kg) to mice of both sexes in order to study its acute toxicity. Analgesic activity was evaluated in mice and rats using acetic acid-induced writhing and formalin tests at doses of 250, 500 and 1000 mg/kg. Anti-inflammatory activity was assessed by carrageenan-induced paw oedema method, while the bioactive compounds in the extract were identified by high performance liquid chromatography (HPLC) analysis. Results: The extract (1000 mg/kg) produced significant inhibition in acetic acid-induced writhing (71.18 %) and formalin (83.58 %) tests; and 73.52 % reduction of carrageenan-induced rat paw oedema test (p < 0.001). HPLC analysis revealed the presence of two phenolic acids, viz, salicylic acid (21.81 mg/g dry weight) and rosmarinic acid (28.44 mg/g dry weight); and apigenin, a flavonoid aglycone (5.70 mg/g dry weight). Conclusion: These results indicate that the extract of Deverra scoparia Coss. & Dur. is non-toxic even at a dose of 16g/kg. The extract possesses significant analgesic and anti-inflammatory potential which may be due to the presence of phenolic compounds (apigenin, salicylic acid and rosmarinic acid).

Cite

CITATION STYLE

APA

Harchaoui, L., Chabane, D., & Ouafi, S. (2018). Analgesic and anti-inflammatory properties of aqueous extract of deverra scoparia coss and dur obtained from Tamanrasset, Algeria. Tropical Journal of Pharmaceutical Research, 17(8), 1523–1529. https://doi.org/10.4314/tjpr.v17i8.9

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free