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An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies

Chemical Communications (2015) 51(44) 9169-9172
DOI: 10.1039/c5cc03180j
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Abstract

A new anticancer agent based on the conjugation of a photoactivatable Pt(iv) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing αVβ3 integrin compared to control DU-145 human prostate carcinoma cells.

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Gandioso, A., Shaili, E., Massaguer, A., Artigas, G., González-Cantó, A., Woods, J. A., … Marchán, V. (2015). An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies. Chemical Communications, 51(44), 9169–9172. https://doi.org/10.1039/c5cc03180j

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