Parallel acquisition of slice-selective 1H-1H soft COSY spectra

Abstract

A method is demonstrated for parallel acquisition of several slice selective soft COSY proton spectra. Application of a slice selective mixing pulse in a selective correlation experiment allows slice selective coherence transfer between different coupled spin pairs. During such slice selective coherence transfer, the spin states of the passive spins are undisturbed. In other words, slice selective coherence transfer executes spin-state selective coherence transfer between a given spin and all its coupled neighbours. This results in a final spectrum which contains multiple soft cosy spectra between a given signal(s) and all its coupled signals, significantly reducing experimental time. This provides access to all the couplings for a given proton site and its coupled partners.