Rapid molecular detection of inducible macrolide resistance in Mycobacterium chelonae and M. abscessus strains: A replacement for 14-day susceptibility testing?

Abstract

The erm(41) gene causes inducible macrolide resistance in Mycobacterium abscessus but not Mycobacterium chelonae. erm(41) sequencing of 285 M. abscessus and 45 M. chelonae isolates was compared to 14-day susceptibility; agreement percentages were 98.9% and 100%, respectively. Extended incubation may not be necessary for M. chelonae, and the erm(41) genotype is a useful adjunct for M. abscessus. Copyright © 2014, American Society for Microbiology. All Rights Reserved.