We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production. Synthetic RNA silencing was target-specific and is a new tool for gene regulation and metabolic engineering studies in Streptomyces. © 2013 Uguru et al.
CITATION STYLE
Uguru, G. C., Mondhe, M., Goh, S., Hesketh, A., Bibb, M. J., Good, L., & Stach, J. E. M. (2013). Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2). PLoS ONE, 8(6). https://doi.org/10.1371/journal.pone.0067509
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