Hyaluronic acid accelerates bone repair in human dental sockets: a randomized triple-blind clinical trial

Abstract

This study evaluated the effects of hyaluronic acid (HA) on bonerepair of human dental sockets. Thirty-two lower first premolars wereextracted from 16 patients (2 per patient) for orthodontic reasons. Followingthe extractions, one socket was randomly filled with 1% HA gel, while theother was allowed to naturally fill with blood clot. After 30 and 90 days ofsurgery, patients underwent cone beam computed tomography. Five centralorthoradial slices were captured from each socket. The gray intensity wasmeasured in each image and results were reported as mean percentage ofbone formation. The buccolingual alveolar ridge width was measured anddimensional changes were compared between the postoperative intervals.The pattern of alveolar trabecular bone was evaluated through the fractaldimension. Treated sockets showed a higher percentage of bone formationand fractal dimension values (58.17% and 1.098, respectively) comparedwith controls (48.97% and 1.074, respectively) in the 30-day postoperativeperiod (p < 0.05). After 90 days, there was no significant difference betweengroups. Additionally, no significant difference was found between groupsregarding the alveolar dimensions (p > 0.05). Use of 1% HA gel after toothextraction accelerates bone repair in human dental sockets