Hormonal and biochemical study of the effect of obesity on women infertility

Abstract

Examining the impact of obesity on infertility among women. Via eleven biochemical parameters, such as progesterone, estrogen, Luteinizing Hormone, Follicle-Stimulating-Hormone, Prolactin, Cholesterol, Triglyceride, Thyroid-Stimulating-Hormone, Very-Low-Density-Lipoprotein, High-Density-Lipoprotein, and Low-Density-Lipoprotein, were tested in 107 women with infertility and 54 control group. The result showed there was a significant elevation in the concentration of estrogen, progesterone, FSH, LH, prolactin, TSH, cholesterol, TG, VLDL and LDL in infertile women, compared to the healthy women at a significant level of P = 0.025 (72.1 ± 30.9 pg/mL), P = 0.01 (1.94 ± 0.83 ng/mL), P = 0.019 (5.15 ± 0.12 mlU/mL), P = 0.016 (6.19 ± 3.0 mlU/mL), P = 0.02 (32.7 ± 21.5 pg/mL), P = 0.0013 (2.09 ± 1.04 µlU/mL), P = 0.001(186.3 ± 34.1mg/dL), P = 0.001 (162.5 ± 83.7 mg/dL), P = 0 008 (32.5 ± 16.6 mg/dL) and P = 0.007 (113.3 ± 34.4 mg/dL), respectively. Obesity had a strong positive relationship with LH, cholesterol, TG, VLDL, and LDL, whereas an unwanted correlation with HDL was noted. Also, an association has been found between hormonal and biochemical parameters, and WHR and BMI. WHR demonstrated a significant negative correlation to HDL. Finally, the study showed that obesity is a new indicator of increasing the infertility risk for women of all ages through BMI and WHR.