Preparation and Characterization of Amoxicillin-loaded Chitosan Nanoparticles to Enhance Antibacterial Activity Against Dental Decay Pathogens

Abstract

Nanotechnology’s dental applications and application time are investigated. Selective dentin caries removal improves pulp tissue without surgery. Modern caries therapy cures the disease, saves pulp, and remineralizes teeth. Chitosan nanoparticles administer Amoxicillin intracellularly to treat bacterial infections. Chitosan nanoparticles are produced by tri-polyphosphate ionic gelation. Chitosan nanoparticle size and sodium tri poly phosphate (TPP) concentrations were examined to maximize chitosan nanoparticle size. The pH and ultrasonication time were also constant. SEM and FT-IR describe chitosan nanoparticles. Chitosan nanoparticles and their loaded antibiotics kill and inhibit Cariogenic gram (+) bacteria because of their nanoparticle morphologies. Antibacterial activity improved with antibiotic loading.