Role of quantitative diffusion-weighted imaging in differentiation between red and infiltrated marrow in pediatric patients with hematologic malignancy

Abstract

Background: To evaluate the role of DWI with ADC value measurement in the differentiation between bone marrow infiltration and normal red marrow in pediatric patients with hematologic malignancies Results: Significant results were obtained between ADC values of normal red and infiltrated marrow (p < 0.005). ADC values were significantly lower in infiltrative marrow lesions. The cutoff ADC value for benign and malignant lesions was 0.612 × 10−3 mm2/s. Conclusion: DWI with ADC value has an additive role in differentiation between infiltrative lesions from foci of red marrow in patients with hematological malignancies.