Locked and unlocked nucleosides in functional nucleic acids

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Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes. © 2011 by the authors; licensee MDPI, Basel, Switzerland.




Doessing, H., & Vester, B. (2011, June). Locked and unlocked nucleosides in functional nucleic acids. Molecules. https://doi.org/10.3390/molecules16064511

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