Osseous reactions to three hemostatic agents

Abstract

The effects of bone wax, Surgicel, and Gelfoam on bone healing were evaluated microscopically using two different intraosseous implantation techniques. Experimental defects were made in both tibias of rats. Test materials were placed in defects in right tibias and were left in situ for the duration of the experiment. Likewise, materials were placed in left tibial defects and then were removed as completely as possible after 10 min. All three hemostatic agents affected healing when left in situ. Bone wax inhibited osteogenesis. Surgicel markedly slowed the rate of repair and caused inflammation. Gelfoam was usually completely resorbed and healing was complete 120 days after surgery. Residues of test materials were observed in most left tibial defects and they elicited reactions that were qualitatively similar but quantitatively less involved than those observed in the right tibias. These results indicate that careful removal of hemostatic agents during periapical surgery aids healing. © 1985 The American Association of Endodontists.