Frequency-dependent response in cortical network with periodic electrical stimulation

Abstract

Electrical stimulation can shape oscillations in brain activity. However, the mechanism of how periodic electrical stimulation modulates brain oscillations by time-delayed neural networks is poorly understood at present. To address this question, we investigate the effects of periodic stimulations on the oscillations generated via a time-delayed neural network. We specifically study the effect of unipolar and asymmetric bidirectional pulse stimulations by altering amplitude and frequency in a systematic manner. Our findings suggest that electrical stimulations play a central role in altering oscillations in the time-delayed neural network and that these alterations are strongly dependent on the stimulus frequency. We observe that the time-delayed neural network responds differently as the stimulation frequency is altered, as manifested by changes in resonance, entrainment, non-linear oscillation, or oscillation suppression. The results also indicate that the network presents similar response activities with increasing stimulus frequency under different excitation-inhibition ratios. Collectively, our findings pave the way for exploring the potential mechanism underlying the frequency-dependent modulation of network activity via electrical stimulations and provide new insights into possible electrical stimulation therapies to the neurological and psychological disorders in clinical practice.