Two new diterpenoids from leonurus japonicus

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Abstract

Two new labdane-type diterpenoids, 5-ethoxy-3-(2-((R)-4-hydroxy-2,5,5,8a-tetramethyl-3-oxo-3,5,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)furan-2(5H)-one (1), and 5-hydroxy-4-(2-((1R,3S,7aS)-1-hydroxy-4,4,7a-trimethyl-3-propionyloctahydroisobenzofuran-1-yl)ethyl)furan-2(5H)-one (2), wereisolated from the EtOH extract of the herb of Leonurus japonicus Houtt., Lamiaceae. Their chemicalstructures were determined by analysis of 1D, 2D NMR, HRESIMS, and by comparison with knownanalogs.

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Wu, H., Wang, S., Liu, H., Yan, E., Li, Y., Liu, R., … Shi, Y. (2015). Two new diterpenoids from leonurus japonicus. Revista Brasileira de Farmacognosia, 25(2), 180–182. https://doi.org/10.1016/j.bjp.2015.02.006

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