Amide Acetal in Palladium-Catalyzed Allylation with Allylic Alcohols under Neutral Conditions

Abstract

A mild and efficient palladium-catalyzed allylation reaction with allylic alcohols is described. The in situ activation of the allylic alcohol is achieved by using N,N-dimethylacetamide dimethyl acetal and a simple palladium catalyst (i.e., Pd(PPh3)4). The reaction system does not require acid or base additives or specially designed ligands. In addition to carbon nucleophiles, nitrogen and oxygen nucleophiles can also be used with the allylic alcohol in this transformation.