Spontaneous redistribution of surface immunoglobulin in the motile b lymphocyte*

Abstract

This paper reports that B cells undergoing translatory motion spontaneously segregate their surface Ig to one portion of their plasma membrane. The spontaneous redistribution of surface Ig was found to be: (a) selective, concanavalin Abinding sites and H-2 antigens were not redistributed; and (b) absolutely dependent on translatory motion and energy metabolism. Abundant B cells undergoing motility were found after cultures in lipopolysaccharide or trypsin, or after brief exposure to cholinergic drugs. © 1976, Rockefeller University Press., All rights reserved.