Abstract
A novel class of Growth Hormone Secretagogues (GHS), based on a tetrazole template, has been discovered. In vitro SAR and in vivo potency within this new class of GHS are described. The tetrazole 9q exhibits good oral bioavailability in rats and dogs as well as efficacy following an oral 10 mg/kg dose in dogs. Solution and solid phase protocols for the synthesis of tetrazole based GHS have been developed. © 2007 Elsevier Ltd. All rights reserved.
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Hernández, A. S., Cheng, P. T. W., Musial, C. M., Swartz, S. G., George, R. J., Grover, G., … Tino, J. A. (2007). Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues. Bioorganic and Medicinal Chemistry Letters, 17(21), 5928–5933. https://doi.org/10.1016/j.bmcl.2007.07.099
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