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Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

Organic Process Research and Development
DOI: 10.1021/op500305s
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Abstract

This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale.

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Dunetz, J. R., Magano, J., & Weisenburger, G. A. (2016, February 19). Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals. Organic Process Research and Development. American Chemical Society. https://doi.org/10.1021/op500305s

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