Current approaches to optimize the donor heart for transplantation

Abstract

Heart transplantation remains a critical therapy for patients with end-stage heart failure, offering incremental survival and improved quality of life. One of the key components behind the success of heart transplantation is the condition and preservation of the donor's heart. In this review, we provide a comprehensive overview of ischemic reperfusion injury, risk factors associated with primary graft dysfunction, current use of various preservation solutions for organ procurement, and recent advancements in donor heart procurement technologies. This state-of-the-art review will explore factors associated with bringing the “ideal” donor heart to the operating room in the contemporary era.