Production and optimization of mevastatin using Penicillium citrinum NCIM 768

Abstract

A modified solid-state fermentation was used to produce mevastatin by Penicillium citrinum NCIM 768 recycling wheat bran as carrier. The following optimum conditions of physiochemical parameters of temperature 27°C, pH 4 with a relative humidity of 60% and at an inoculum volume of 2.5 ml, resulted in mevastatin yield of 68.7 mg L -1 in fermentation broth. Among various nitrogen and carbon sources, addition of sodium nitrate and glucose improved mevastatin production.