Antibacterial and immunomodulatory effects of flavonoids

Abstract

The article provides an overview of the antibacterial and immunomodulatory effects of flavonoids. In respect of direct antimicrobial activity, the values of minimum inhibitory concentrations (MICs) of various classes of flavonoids against human pathogens are analyzed. The interaction of flavonoids with antibacterial drugs and the role of flavonoids in the formation of bacterial biofilms are described. Information about the influence of flavonoids on some mechanisms of innate and adaptive immunity of humans and animals are presented. Modern literature data substantiate the prospects of using certain classes of flavonoids in order to increase the effectiveness of antimicrobial pharmacotherapy.