Coevolution of the Human Host and Gut Microbiome: Metagenomics of Microbiota

Abstract

The aim of this study was to characterize the raw material ivermectin (IVC) using different analytical techniques used for drugs with its pharmacological characteristics. Mass spectroscopic and infrared absorption analyses were carried out to identify the molecule, and further analyses to confirm its crystalline structure (electron sweep microscopy and X-ray diffraction), as well as granulometric analysis, apparent, and compacted density, leading to the conclusion that, even with a crystalline structure IVC has good flow and compressibility. Differential Scanning Calorimetry and thermogravimetric analysis were used for the infrared thermal characterization, determination of the melting point (157 °C), initial degradation temperature (305 °C), loss of mass with the increase of the temperature (3 events, the first dissolution and degradation in two consecutive stages). Using the afore-mentioned techniques, it was possible to carry out a compatibility study of IVC with some excipients used in solid pharmaceutical form, which demonstrated an incompatibility between IVC and lactose and amide. These results can be used to develop new pharmaceutical forms and for more rational quality control of forms already commercialized, with better understanding of the characteristics of IVC.