Survival difference between mucinous vs. non-mucinous colorectal cancer following cytoreductive surgery and intraperitoneal chemotherapy

Abstract

Background: It is believed that the oncologic behavior of mucinous colorectal adenocarcinoma (MC) is different from non-mucinous adenocarcinoma (NMC). The aim of the study is to compare long-term survivals between patients with MC and those with NMC following cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC). Methods: This was a retrospective study of prospectively collected data of patients with peritoneal metastases of colorectal origin following CRS and IPC. Group I included patients with MC which was defined as being composed of >50% extracellular mucin. Group II included those with NMC. Subgroup analysis was performed according to the location of primary tumor. Results: A total of 213 patients were included in this study. The two groups had similar hospital mortality, high dependency unit stay. MC group had a significantly longer mean intensive care unit (ICU) stay (p =.037) and total hospital stay (p =.037). There was no significant difference in overall survival (OS) and disease-free survival (DFS) between two groups (p =.657 and p =.938, respectively). Multivariate analysis showed that the presence of mucin was not an independent negative prognostic factor for OS (p =.190). Conclusion: In summary, patients with MC had a similar long-term survival outcome with those with NMC following CRS and IPC.