Correlation of serum 1,5-Ag with uric acid in type 2 diabetes mellitus with different renal functions

Abstract

Aim. Recent studies found that levels of serum uric acid (SUA) were positively associated with serum 1,5-anhydroglucitol (1,5-AG) in subjects with type 2 diabetes mellitus (T2DM). In the current study, we investigated the association between 1,5-AG and UA in T2DM patients with different renal functions. Methods. A total of 405 T2DM patients, 213 men and 192 women, participated in the study. Patients’ clinical information was collected, and serum 1,5-AG, SUA, and other clinical characteristics were measured. Correlation analyses were carried out to analyze their correlation with serum 1,5-AG and SUA. Results. The Male group showed higher levels of SUA than the feMale group (282.1 ± 91.2 and 244.7 ± 71.89 μmol/L, respectively, P < 0 01). Pearson’s correlation coefficients determine that SUA was positively associated with 1,5-AG in both men (r = 0 213, P < 0 05) and women (r = 0 223, P < 0 05), and such relationship can be influenced by the renal function. The positive association still existed with moderate impaired renal function. Moreover, 1,5-AG had a negative association with haemoglobin A1c (HbA1c) in T2DM subjects with eGFR ≥ 30 mL/min/1.73 m2 (P < 0 01). Conclusion. The positive association between SUA and 1,5-AG still exists in T2DM with moderate renal failure. 1,5-AG can still reflect the glucose levels in patients with CKD stages 1-3.