Chitosan nanoparticles loaded hydrogels promote skin wound healing through the modulation of reactive oxygen species

Abstract

This study developed a novel bioactive chitosan nanoparticle loaded calcium alginate hydrogel to regulate inflammation and neovascularization for accelerated wound healing in vivo. It was found that chitosan nanoparticles loaded calcium alginate hydrogel exhibited remarkable antibacterial activity. Through the modulation of generation of ROS, it promoted the synthesis and secretion of IL-6 in vascular endothelial cell (VEC), suggesting its potential proinflammatory activation. Further, it promoted VEC invasion, metastasis and neovascularization to accelerate wound healing.