Cyclic Guanidines. IX. Synthesis of 2-Amino-3,4-dihydroquinazolines as Blood Platelet Aggregation Inhibitors

Abstract

A series of aryl- or aralky-substituted 2-amino-3,4-dihydroquinazolines and related compounds were synthesized. The compounds were evaluated for inhibitory activity towards collagen- and ADP-induced aggregation of rat blood platelet in vitro and ex vivo. A group of 3-benzyl-substituted derivatives had potent activity. The structure-activity relationships are discussed. © 1980, The Pharmaceutical Society of Japan. All rights reserved.