Highly efficient stereoconservative syntheses of new, bifunctional atropisomeric organocatalysts

Abstract

The first synthesis of new organocatalysts with 1-phenylpyrrole atropisomeric skeleton containing a thiourea group is reported. A possible structural reason for the stereochemical lability of an atropisomeric intermediate is described together with a way to preserve the isomeric purity during the synthesis. The catalytic activities of the new atropisomeric organocatalysts have been tested in Michael addition reactions.