The association of VDR polymorphisms and type 2 diabetes in older people living in community in Santiago de Chile

Abstract

Introduction: Several polymorphisms have been associated with obesity and type 2 diabetes in different populations. Objective: To investigate the frequencies of a genetic polymorphism of Vitamin D receptor (FokI and BsmI) in patients with T2D. Methods: The case-control study was conducted in 138 patients with T2D and 172 control subjects, men and women (60-79 years old). The genotype and allele frequency determination of VDR polymorphisms were determined in these subjects. Results: The frequency of the C allele of the FokI polymorphism was significantly higher in the T2D group than in healthy subjects (p = 0.025). The frequencies of the BsmI variant were similar in subjects with and without T2D (p = 0.747). Consistent with these data, there was an association of the C allele with T2D (OR = 1.74, 95% CI = 1.003-3.084, p = 0.036), but not the AG + GG variants for BsmI (OR = 1.02, 95% CI = 0.635-1.649, p = 0.916). We can observe a significant association between carrier of the T > C variant of FokI and type 2 diabetes, adjusted for Vitamin D, age, obesity (overweight and obesity), seasonality, sex and Homa-IR. Here, we show a significant association between the FokI polymorphisms (TC + CC) and T2D with an odds ratio of 1.9001 (95% CI (1.0970-3.6838), p = 0.041). Conclusion: Our study suggests that the C allele (TC + CC) of the VDR-FokI gene is a possible risk factor for T2D in older people living in a community in Santiago de Chile.