Size Controlled Synthesis of One - dimensional Single Crystalline Hydroxyapatite Nanorods by Hydrothermal Method

Abstract

Hydroayapatite (HAp) nanorods were widely used in biomedical fields such as multifunctional drug delivery systems, bone tissue damages and for dental applications. Here, rod shaped HAp nanoparticles with uniform morphology and controllable size were successfully synthesized without any templates by hydrothermal method. Powder X-Ray diffractometer (XRD), Optical Micrographs (OM), Nitrogen adsorption and desorption studies (BET), Field Emission Scanning Electron Microscope (FE-SEM) and Transmission Electron Microscope (TEM) were used to characterize the structure and composition of the prepared HAp samples. The biocompatibility of the prepared nanorods was tested against MG 63 human osteosarcoma cell lines using MTT assay. The results confirmed that the synthesized HAp nanorods are biocompatible, high purity in nature and high aspect ratio with mean width of 10 nm and mean length of 100 nm. Thus the prepared hydroayapatite nanorods can be used as drug carrying vehicles for hard tissue repair, bone regeneration, bone tissue engineering applications and as strength-enhancing additives for the preparation of biocompatible nanocomposites with improved mechanical properties.