Synthesis and biological study of some new naphtho[2,1-b]furan and related heterocyclic systems

Abstract

In the reaction of 1-cyano-2-naphthol (4) or its sodium salt with different alkylating agent, the O-alkylated derivatives (5a-d) were produced which underwent ring closure reactions using sodium ethoxide solution to give aminonaphtho [2,1-b]furan derivatives (6a-d). Ethyl 3-aminonaphtho[2,1-b]furan- 2-carboxylate (8) was reacted with formamide to afford naphtho[1′, 2′:4,5]furo[3,2-dlpyrimidine (11) derivatives. The produced pyrimidino compound underwent various reactions to synthesise other heterocyclic compounds.