Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: Effect of ligands on the affinity of the E. coli methionine repressor, MetJ, for its operator DNA

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Abstract

The efficient synthesis of a range of stable SAM mimetics, and their ability to promote the binding of the E. coli methionine repressor (MetJ) to its operator DNA, is described. © 2009 The Royal Society of Chemistry.

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Joce, C., Caryl, J., Stockley, P. G., Warriner, S., & Nelson, A. (2009). Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: Effect of ligands on the affinity of the E. coli methionine repressor, MetJ, for its operator DNA. Organic and Biomolecular Chemistry, 7(4), 635–638. https://doi.org/10.1039/b816495a

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