Effect of Ethanol Extract Sonchus arvensis Linn Leaves on Acute Toxicity in Healthy Male Albino rat (Rattus norvegicus)

Abstract

Sonchus leaves are traditional plants whose effects have been widely studied including immunostimulants and diuretics. Both of these effects have benefits for maintaining health and treating diseases. The purpose of this study was to determine the acute toxic effects on healthy male albino rat after being extracted 1 time a day for 14 days. Each group of test animals was given a dose of of 700, 1400, 2800, 5600 (mg/KgBW) every 10 healthy male albino rat (n=40) for acute toxicity test and toxicity tests were observed for 14 days. The albino rat in all groups were observed for behaviour, body weight development. The data obtained were statistically tested with Shapiro Wilk normality test, or Friedman followed by Wilcoxon test and calculated LD50. No deaths occurred in each dose group given ethanol extract Sonchus. Based on the average body weight in the dose group compared to the 0th, 7th, and 14th days has decreased. Statistics show that there were significant differences (p<0.05) between observations day 0-7, day 0-14, day 7-14 and also comparison between all groups. Ethanol extract sonchus did not provide toxic effects on healthy male albino rat tetapi memberikan penurunan berat badan pad tikus.