Tandem heck/decarboxylation/heck strategy: Protecting-group-free synthesis of symmetric and unsymmetric hydroxylated stilbenoids

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Abstract

Ride the (micro)wave: The title strategy has been developed for the synthesis of various symmetric or unsymmetric hydroxylated stilbenoids utilizing 4-halophenols and acrylic acid as coupling partners (see scheme; DMA=N,N-dimethylacetamide, MW=microwave). Protecting groups are not necessary and a single palladium catalyst is used. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Shard, A., Sharma, N., Bharti, R., Dadhwal, S., Kumar, R., & Sinha, A. K. (2012). Tandem heck/decarboxylation/heck strategy: Protecting-group-free synthesis of symmetric and unsymmetric hydroxylated stilbenoids. Angewandte Chemie - International Edition, 51(49), 12250–12253. https://doi.org/10.1002/anie.201206346

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