Progress toward elimination mother-to-child transmission of HBV in Shandong Province, China: Coverage trend in hepatitis B vaccination and HBIG administration, 2017–2024

Abstract

To evaluate progress toward MTCT elimination of HBV, we analyzed 8-y trends in hepatitis B vaccine (HepB) and hepatitis B immune globulin (HBIG) administration coverage rates in Shandong province, focusing on high-risk populations. Data were collected from a provincial system, Shandong Vaccination Information System. Information of maternal HBsAg+ neonates born in 2017–2024 were extracted. Administration coverage in four groups (A: general newborn, B: maternal HBsAg+ neonates, C: preterm neonates with HBsAg+ mother, and D: birthweight <2000 g (LBW2000) neonates with HBsAg+ mother) were calculated. Joinpoint models were used to analyze changing trends over time, calculating annual percentage change (APC). From 2017 to 2024, the maternal HBsAg+ rate dropped from 2.85% to 2.10% (APC = -0.10, P