Antiviral and Anticancer Activity from Curcuma longa L. and Tamarindus indica Bioactive Compounds through In Silico Analysis

Abstract

Various efforts are made for the discovery and development of an effective and safe treatment as a solution to the problem. One of the approaches used in this study is the development of drugs based on natural ingredients such as Curcuma longa L. and Tamarindus indica with various known health benefits. In this study, in silico analysis was conducted to evaluate the potential antiviral and anticancer activities of bioactive compounds contained in Curcuma longa L. and Tamarindus indica. The in silico method used in this study consists of the preparation of ligand samples from Tamarindus indica and Curcuma longa L. in the compound database (PubChem) and identification of the probability of potential query compounds through the PASSOnline server to determine the potential as antiviral and anticancer. Tamarindus indica and Curcuma longa L. are predicted to act as effective antiviral and anticancer candidates because the probability of bioactivity activation is higher than inhibition. Campesterol and α-Amyrin compounds are potential compounds from Tamarindus indica. Quercetin from Curcuma longa L. may have dual activity as antiviral and anticancer.