Global epidemiology of lower extremity artery disease in the 21st century (2000–21): a systematic review and meta-analysis

Abstract

Aims The epidemiology of lower extremity artery disease (LEAD) is evolving. This meta-analysis of aggregate data aimed to (i) determine the global prevalence of LEAD and by regions in the 21st century and (ii) update the associated risk factors in this period. Methods A systematic literature review was performed through PubMed, Cochrane, Scopus, Science Direct, and Google Scholar da- and results tabases, restricted to general population studies between January 2000 and September 2021, with LEAD defined by a low (