Production and Efficacy of Peste des Petits Ruminants Vaccine 75/1 in the Kingdom of Saudi Arabia

Abstract

A freeze dried live attenuated vaccine against peste des petits ruminants (PPR) infection was prepared by growing an attenuated PPR strain 75/1 in vero cell culture. The produced vaccine batch that had a titre of 2x6.3 log 10 TCID50/100 dose was safe and potent. The mean titre of PPRV-neutralizing antibodies was 2.2 log 10 at the 21st day post-vaccination. The vaccine was thermostable when stored at 4C for 360 days. The reconstituted vaccine was still within the recommended titre after keeping at 20C for 8 hours, 37C for 4 hours and 45C for 1 hour.