Digger: directed annotation of immunoglobulin and T cell receptor V, D, and J gene sequences and assemblies

Abstract

Knowledge of immunoglobulin and T cell receptor encoding genes is derived from high-quality genomic sequencing. High-throughput sequencing is delivering large volumes of data, and precise, high-throughput approaches to annotation are needed. Digger is an automated tool that identifies coding and regulatory regions of these genes, with results comparable to those obtained by current expert curational methods. Availability and implementation: Digger is published under open source license at https://github.com/williamdlees/Digger and is available as a Python package and a Docker container.