Glutamina sérica como factor predictivo de insuficiencia renal en pacientes oncológicos tratados con quimioterapia basada en cisplatino

Abstract

Purpose: Glutamine is a vehicle transporting non-toxic nitrogen in the blood. High levels of glutamine are present in renal failure. We studied glutamine searching possible predictive factors associated to the development of renal failure secondary to cisplatin. Material and methods: We studied 34 patients with different tumors treated with cisplatin-based chemotherapy. We determined the serum amino acid three days after each infusion. Results: Glutamine concentration along the chemotherapy cycles was higher in the patients with renal failure. Glutamine level >1000 μM/L determined after cisplatin administration was strongly predictive of developing renal failure. Conclusions: The elevation of serum glutamine has a significant predictive value of developing renal failure secondary to cisplatin.