COPS5 (Jab1) Protein increases β Site processing of amyloid precursor protein and amyloid βpeptide generation by stabilizing ranbp9 protein levels

Abstract

Background: Increased generation of toxic amyloidβpeptide (Aβ) in the brain is central to the pathogenesis of Alzheimer's disease (AD). Results: COPS5 (Jab1) is a novel RanBP9-interacting protein that robustly increases Aβgeneration Conclusion: COPS5 increases Aβgeneration by stabilizing RanBP9 protein levels. Significance: Lowering COPS5 levels may be an effective therapeutic approach for AD. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.