Basic and clinical studies on me1207

Abstract

We performed basic and clinical studies on ME1207, a new oral cephalosporin, and obtained the following results. The in vitro antibacterial activity of ME 1206, an active metabolite of ME1207, against 285 clinical isolates from 17 species was compared with that of cefpodoxime, ceftibuten, cefdinir, cefprozil, ofloxacin, clavulanic acid /amoxicillin, cefixime and cefteram. ME1206 was more effective against gram-positive bacteria than other cephalosporins except cefdinir, and the MICs of ME1206 against gram-negative bacteria were equal to that of cefteram. In clinical studies, ME1207 was administered to 11 patients with respiratory infections; the clinical response was excellent in 3 cases, good in 6, poor in 1 and unknown in 1. Side effects and abnormal laboratory findings were observed in 2 cases. © 1992, Japanese Society of Chemotherapy. All rights reserved.