Emergence of blaNDM-1 associated with the aac(6’)-ib-cr, acrB, cps, and mrkD genes in a clinical isolate of multi-drug resistant Klebsiella pneumoniae from Recife-PE, Brazil

Abstract

Introduction: The emergence of New Delhi metallo-β-lactamase (NDM) is concernig because it reduces the antibiotic therapy options for bacterial infections. Methods: Resistant and virulent genes from an isolate of Klebsiella pneumoniae derived from a patient with sepsis in a hospital in Recife-PE, Brazil, were investigated using PCR and DNA sequencing. Results: blaNDM-1, aac(6’)-Ib-cr and acrB resistance genes, and cps and mrkD virulence genes were detected. Conclusions: To our knowledge, this is the first report on blaNDM-1 in Recife-PE. This detection alerts researchers to the need to control the spread of blaNDM-1 resistance gene by this bacterium in Brazil.