PBK/TOPK expression predicts prognosis in oral cancer

37Citations
Citations of this article
32Readers
Mendeley users who have this article in their library.

Abstract

Oral cancer is a common cancer with poor prognosis. We evaluated the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its prognostic significance in oral cancer. PBK/TOPK expression was measured by immunohistochemical staining of samples from 287 patients with oral cancer. The association between PBK/TOPK expression and clinicopathological features was analyzed. The prognostic value of PBK/TOPK for overall survival was determined by Kaplan-Meier analysis and Cox proportional hazard models. A high PBK/TOPK expression level was correlated with long overall survival. The prognostic role of PBK/TOPK expression was significant in young patients (p < 0.05), patients with smoking habits (p < 0.05), and late stage disease (p < 0.05). Our results suggest that PBK/TOPK expression is enhanced in oral cancer. High PBK/TOPK expression, either alone or in subgroups according to clinicopathological features, may serve as a favorable prognostic marker for patients with oral cancer.

References Powered by Scopus

Characterization of PDZ-binding kinase, a mitotic kinase

189Citations
N/AReaders
Get full text

PDZ-binding kinase/T-LAK cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast cancer

169Citations
N/AReaders
Get full text

Oxidative and antioxidative mechanisms in oral cancer and precancer: A review

154Citations
N/AReaders
Get full text

Cited by Powered by Scopus

T-LAK cell-originated protein kinase (TOPK): an emerging target for cancer-specific therapeutics

61Citations
N/AReaders
Get full text

PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma

53Citations
N/AReaders
Get full text

Six novel biomarkers for diagnosis and prognosis of esophageal squamous cell carcinoma: Validated by scRNA-seq and qPCR

42Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Chang, C. F., Chen, S. L., Sung, W. W., Hsieh, M. J., Hsu, H. T., Chen, L. H., … Chou, M. C. (2016). PBK/TOPK expression predicts prognosis in oral cancer. International Journal of Molecular Sciences, 17(7). https://doi.org/10.3390/ijms17071007

Readers over time

‘16‘17‘18‘19‘20‘21‘22‘23‘2402468

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 10

67%

Professor / Associate Prof. 2

13%

Researcher 2

13%

Lecturer / Post doc 1

7%

Readers' Discipline

Tooltip

Medicine and Dentistry 8

50%

Biochemistry, Genetics and Molecular Bi... 4

25%

Nursing and Health Professions 2

13%

Engineering 2

13%

Article Metrics

Tooltip
Social Media
Shares, Likes & Comments: 1

Save time finding and organizing research with Mendeley

Sign up for free
0