Two new triterpenoid saponins from the root of Platycodon grandiflorum

Abstract

Two new triterpenoid saponins, named platycodon A (3-O-β-D- glucopyranosyl-16-O-β-D-glucopyranosyl-2β,3β,16β, 21β-tetrahydroxyolean-12-en-28-oic acid) and platycodon B (3-O-β-D-glucopyranosyl16-O-β-D-xylopyranosyl-2β,3β, 16β,21β-tetrahydroxyolean-12-en-28-oic acid) were isolated from the roots of Platycodon grandiflorum. The structures of these compounds were elucidated by means of various spectroscopic analyses. Compounds 1 and 2 were tested in HepG-2, A549 and DU145 human cancer cell lines and showed remarkable cytotoxic activities against HepG-2 and A549 cancer cell lines with IC 50 values ranging from 4.9 to 9.4μM, but they displayed weak cytotoxic activities against DU145 cancer cell line with IC50 values greater than 10μm. © 2013 The Pharmaceutical Society of Japan.