The transcription factor NF-κB plays crucial roles in the regulation of inflammation and mmune responses, and inappropriate NF-κB activity has been linked with many autoimmune and inflammatory diseases, including rheumatoid arthritis. Cells employ a multilayered control system to keep NF-κB signalling in check, including a repertoire of negative feedback regulators ensuring termination of NF-κB responses. Here we will review various negative regulatory mechanisms that have evolved to control NF-κB signalling and which have been implicated in the pathogenesis of rheumatoid arthritis. © 2011 BioMed Central Ltd.
CITATION STYLE
van Loo, G., & Beyaert, R. (2011, May 31). Negative regulation of NF-κB and its involvement in rheumatoid arthritis. Arthritis Research and Therapy. https://doi.org/10.1186/ar3324
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