THU0537 ANGIOMATOID FIBROUS HISTIOCYTOMA MIMICKING SYSTEMIC JIA VIA MUTATION-DRIVEN IL-6 PRODUCTION

Abstract

Background: Angiomatoid Fibrous Histiocytoma mimicking Systemic JIA via mutation-driven IL-6 production: Angiomatoid Fibrous Histiocytoma (AFH) is a rare tumour associated with mutation-driven production of Interleukin-6 (IL-6) which causes a systemic inflammatory picture similar to Systemic Juvenile Idiopathic Arthritis (sJIA).